Our results support the notion that the catheterization procedure per se may represent a source of haemostatic activation and that the ionic contrast agent studied has insufficient anticoagulant effect to prevent clotting activation being induced by the contrast medium.
Both agents activated these systems to a limited, but identical, degree. Contiene como ingrediente activo Iopamidol al 61. Contrary to the findings from in vitro studies, we found no significant differences between the effects of the non-ionic Iopromide and the ionic Ioxaglate on coagulation and platelets. IOPAMIRO® 300 es el Medio de Contraste Radiológico Hidrosoluble, No Iónico de Baja Osmolaridad. The haemorheological effects were compatible with haemodilution by 5-8%, again without differences between the contrast agents. The degree of activation was similar for both agents. Both Iopromide and Ioxaglate caused further increases in thrombin-antithrombin complex, prothrombin fragments 1 + 2 and beta-thromboglobulin. Indications for activation of coagulation and platelets were already found in nearly 50% of the patients before any contrast medium was given. Blood for laboratory investigations was collected before, and 5 and 30 min after, administering the contrast medium. Either Iopromide (n = 16 median volume 102 ml 95% confidence interval 90-108 ml) or Ioxaglate (n = 15 median 105 ml 95% confidence interval 95-114 ml) was given to 31 patients scheduled for abdominal and femoral arteriography. A large number of haemostatic parameters, including activation markers, were measured. Tecnología Médica DEFINICION Puede definirse como un elemento o una sustancia que una vez inyectada en un vaso sanguíneo o cavidad del organismo humano permite observar estructuras que normalmente no son visibles o se observan deficientemente. The aim was to investigate in vivo whether a non-ionic contrast agent is less anticoagulant or more pro-thrombotic than an ionic medium. In this prospective, double-blind, randomized study the effects of a non-ionic contrast medium (Iopromide) on the haemostatic system were compared with those of a low osmolar ionic medium (Ioxaglate).
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